Software development tools: A bibliography, appendix C.

A bibliography containing approximately 200 citations on tools which help software developers perform some development task (such as text manipulation, testing, etc.), and which would not necessarily be found as part of a computing facility is given. The bibliography comes from a relatively random sampling of the literature and is not complete. But it is indicative of the nature and range of tools currently being prepared or currently available

Software development environments: A bibliography, appendix G

A bibliography containing approximately 100 citations on software development environments is given. The bibliography comes from a relatively random sampling of the literature and is not complete

Software development environments: Present and future, appendix D

Computerized environments which facilitate the development of appropriately functioning software systems are discussed. Their current status is reviewed and several trends exhibited by their history are identified. A number of principles, some at (slight) variance with the historical trends, are suggested and it is argued that observance of these principles is critical to achieving truly effective and efficient software development support environments

An assessment of DREAM, appendix E

The design realization, evaluation and modelling (DREAM) system is evaluated. A short history of the DREAM research project is given as well as the significant characteristics of DREAM as a development environment. The design notation which is the basis for the DREAM system is reviewed, and the development tools envisioned as part of DREAM are discussed. Insights into development environments and their production are presented and used to make suggestions for future work in the area of development environments

Software development environment, appendix F

The current status in the area of software development environments is assessed. The purposes of environments, the types of environments, the constituents of an environment, the issue of environment integration, and the problems which must be solved in preparing an environment are discussed. Some general maxims to guide near-term future work are proposed

Flight software requirements and design support system

The desirability and feasibility of computer-augmented support for the pre-implementation activities occurring during the development of flight control software was investigated. The specific topics to be investigated were the capabilities to be included in a pre-implementation support system for flight control software system development, and the specification of a preliminary design for such a system. Further, the pre-implementation support system was to be characterized and specified under the constraints that it: (1) support both description and assessment of flight control software requirements definitions and design specification; (2) account for known software description and assessment techniques; (3) be compatible with existing and planned NASA flight control software development support system; and (4) does not impose, but may encourage, specific development technologies. An overview of the results is given

Radial Velocities of Six OB Stars

We present new results from a radial velocity study of six bright OB stars with little or no prior measurements. One of these, HD 45314, may be a long-period binary, but the velocity variations of this Be star may be related to changes in its circumstellar disk. Significant velocity variations were also found for HD 60848 (possibly related to nonradial pulsations) and HD 61827 (related to wind variations). The other three targets, HD 46150, HD 54879, and HD 206183, are constant velocity objects, but we note that HD 54879 has H$\alpha$ emission that may originate from a binary companion. We illustrate the average red spectrum of each target.Comment: Accepted for publication in PASP July 2007 issu

Trajectory Model Validation Using Newly Developed Altitude-Controlled Balloons During the International Consortium for Atmospheric Research on Transport and Transformations 2004 Campaign

During the summer of 2004, five altitude-controlled tracking balloons were flown as part of the International Consortium for Atmospheric Research on Transport and Transformations (ICARTT) campaign. These Controlled Meteorological (CMET) balloons, newly developed at the University of Massachusetts, are notable for their light weight (∼1 kg mass), efficient altitude control, case of launch, long-duration flight capability, and ability to perform repeated quasi-Lagrangian soundings. The balloons were embedded in urban plumes from New York and Boston which they tracked over New England, eastern Canada, and the Atlantic Ocean while maintaining a nearly constant altitude. The flights ranged from 10 to 111 hours and covered a maximum distance of 3000 km. Balloon flight tracks are used here to assess the accuracy of trajectory models during intensive aircraft sampling periods. A new method is presented for increasing the number of available reference trajectories by dividing the balloon flights into shorter segments for statistical analysis. For trajectory durations between 2 and 12 hours, mean trajectory errors are found to be approximately 26% and 34% of the flight distance for ECMWF-based and GFS-based trajectories, respectively. Anomalously large model errors observed during three of the flights are found to be the result of a narrow low-level jet (15 July) and synoptic-scale flow patterns (9 and 10 August). The results from this study should be useful to researchers evaluating the performance of trajectory models and chemical transport models during the ICARTT campaign. Complete CMET balloon and model trajectory data sets are available as a supplement to this paper

Neoadjuvant chemotherapy and trastuzumab versus neoadjuvant chemotherapy followed by post-operative trastuzumab for patients with HER2-positive breast cancer

Neoadjuvant chemotherapy plus trastuzumab (NCT) increases the rate of pathological complete response (pCR) and event-free survival (EFS) compared to neoadjuvant chemotherapy (NC) alone in women with HER2 positive breast cancer (BC). pCR in this setting is associated with improved EFS. Whether NCT preferentially improves EFS in comparison to NC followed by adjuvant trastuzumab initiated postoperatively (NCAT) has not been addressed. Using clinical data from women with HER2 positive BC treated at 7 European institutions between 2007 and 2010 we sought to investigate the impact on breast cancer outcomes of concomitant (NCT) versus sequential (NCAT) treatment in HER2 positive early BC. The unadjusted hazard ratio (HR) for event free survival with NCT compared with NCAT was 0.63 (95% CI 0.37–1.08; p = 0.091). Multivariable analysis revealed that treatment group, tumour size and ER status were significantly associated with EFS from diagnosis. In the whole group NCT was associated with a reduced risk of an event relative to NCAT, an effect that was confined to ER negative (HR: 0.25; 95% CI, 0.10–0.62; p = 0.003) as opposed to ER positive tumours (HR: 1.07; 95% CI, 0.46–2.52; p = 0.869). HER2 positive/ER negative BC treated with NC gain greatest survival benefit when trastuzumab is administered in both the neoadjuvant and adjuvant period rather than in the adjuvant period alone. These data support the early introduction of targeted combination therapy in HER2 positive/ER negative BC

Thirty Meter Telescope Site Testing I: Overview

As part of the conceptual and preliminary design processes of the Thirty Meter Telescope (TMT), the TMT site testing team has spent the last five years measuring the atmospheric properties of five candidate mountains in North and South America with an unprecedented array of instrumentation. The site testing period was preceded by several years of analyses selecting the five candidates, Cerros Tolar, Armazones and Tolonchar in northern Chile; San Pedro Martir in Baja California, Mexico and the 13 North (13N) site on Mauna Kea, Hawaii. Site testing was concluded by the selection of two remaining sites for further consideration, Armazones and Mauna Kea 13N. It showed that all five candidates are excellent sites for an extremely large astronomical observatory and that none of the sites stands out as the obvious and only logical choice based on its combined properties. This is the first article in a series discussing the TMT site testing project.Comment: Accepted for publication in PASP, April 2009 issu